Research - Current Research

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Project title: Quantifying CSF Flow Dynamics Using Real-time MRI
Principal Investigator: Karim Sabra, PhD
Institution: Georgia Tech Research Corporation
Period of Performance: September 2015-August 2016
Award: $50,000.00
Summary of Research: This project aims 1) to quantitatively measure in real-time and non-invasively the cerebrospinal fluid (CSF) flow dynamics using a novel magnetic resonance imaging (MRI) technique in order to investigate the effects of respiration and transient events, such as coughing and sneezing, on SCF flow along the spine, and 2) to determine the applicability of this MRI method to improve the diagnosis of craniospinal disorders and better understand the role CSF flow plays in the pain symptoms experienced by Chiari malformation and syringomyelia patients.

Project title: Postoperative Syringomyelia Resolution in Canine Chiari Like Malformation
Principal Investigator: Lauren R Talarico, BS, DVM, CACVIM
Institution: VCA SouthPaws Veterinary Specialty and Emergency Center
Period of Performance: December 2014-November 2015
Award: $57,000.00
Summary of Research: Malformation of the caudal aspect of the skull, similar to Chiari type I disorder of people, has been documented in many breeds of dogs. Even though approximately 95% of all Cavalier King Charles Spaniels are affected by Chiari-like malformation (CLM) other breeds of dogs such as Yorkshire Terriers and Chihuahuas are also commonly affected.
Aims:
1. To determine objective measurements of syrinx size pre and post-operatively and how changes in the size of the syrinx differs between persistently symptomatic and clinically improved postoperative patients.
2. To correlate the above findings with published human data to determine if cross species differences exist and to look for etiologic clues for this disease in both populations, particularly looking at the variable presentation of Chiari in the human population. This may also help to define which patients are at risk due to the lack of posterior fossa volume versus an obstruction of CSF flow at the outlet.

1 year report

2014 Reports Click on title to watch video presentation.

In Vivo and In Vitro CSF flow Studies in Chiari Malformation An ASAP funded research project, presented by Dr Bryn Martin

Comparative Analysis of Posterior Fossa Volumes in Symptomatic versus Asymptomatic Chiari Malformation
Alan Siu, MD

Multicenter in vitro Assessment of 4D PC MRI for Quantification of Cerebrospinal Fluid Motion in Chiari Malformation and Syringomyelia
Bryn A Martin, PhD

Is CSF Flow the “Holy Grail” to determining Clinic-pathological Significance of Chiari Malformation?
Mark Quigley, PhD

Outcome Studies
Bermans Iskandar, MD

The Genetics of Chiari Type I Malformation (CMI) with or without Syringomyelia
Dr. Allison Ashley-Koch, Center for Human Genetics, Duke University Medical School, Durham, North Carolina

Outcomes in Patients Undergoing Surgical Intervention for Chiari Type I Malformation with Syringomyelia
Bermans J. Iskandar, MD, University of Wisconsin at Madison, Tim M. George, MD, University of Texas at Austin